国家自然科学基金青年基金81301568;四川省教育厅自然科学重点项目17ZA0181;四川省卫生和计划生育委员会科研课题17PJ165;西南医科大学校级基金青年基金2018-ZRQN-141;National Natural Science Foundation of China Youth Fund81301568;Key Natural science projects of Sichuan Provincial Education Departmen17ZA0181;Scientific Research Project of Sichuan Health and Family Planning Commission17PJ165;Youth Fund of Southwest Medical University2018-ZRQN-141