国家自然科学基金青年科学基金81601545;重庆市科委科技计划项目cstc2014jcyjA10067;重庆市卫生计生委医学科研项目2016MSXM018Youth Foundation of National Natural Science Foundation of China81601545;Science and Technolo-gy Planning Project of Chongqingcstc2014jcyjA10067;Foundation of Chongqing Health and Family Planning Commission2016MSXM018