国家科技支撑计划项目2015BAI12B03;国家卫计委公益性卫生行业科研专项201402009;北京市科技重大专项课题Z171100001017083;National Science and Technology Support Program of China2015BAI12B03;Special Research Fund for Public Wolfare from National Health and Family planning Commission of China201402009;Beijing Major Science and Technology Projects form Beijing Municipal Science and Technology CommissionZ171100001017083