国家自然科学基金81472887、81773335;浙江省自然科学基金LQ16H290001;浙江省基础公益研究计划项目LGF18H110002National Natural Science Foundation of China81472887,81773335;Natural Science Foundation of Zhejiang Province of ChinaLQ16H290001;Basic Public Welfare Research Project of Zhejiang ProvinceLGF18H110002