广东省科技计划2018B020207006、2019B020208005、2019B111103001;广州市科技计划201804010383;广东省医学科研基金A2018462;Science and Technology Program of Guangdong Province2018B020207006, 2019B020208005, 2019B111103001;Guangzhou Science and Technology Plan Project201804010383;Guangdong Medical Research FoundationA2018462