河南省医学科技攻关计划项目201404045;河南省重点科技攻关计划项目142102310076;国家科技重大专项2012ZX10004905-001-003 This work was supported by grants from the Project for Tackling Key Problems in Medical Science in Henan Province201404045;Project for Tacking Key Problems in Scientific Research in Henan Province142102310076;National Science and Technology Major Project of China2012ZX10004905-001-003