北京市自然科学基金7222159;中央高水平医院临床科研业务费BJ-2022-129,BJ-2022-105,BJ-2022-094;中央高校基本科研业务费专项资金资助3332020070;The Natural Science Foundation of Beijing, China7222159;National High Level Hospital Clinical Research FundingBJ-2022-129, BJ-2022-105, BJ-2022-094;The Fundamental Research Funds for the Central Universities3332020070