国家自然科学基金面上项目81670086,81370183;慢性病防治科技重大专项项目17ZXMFSY00080;天津市自然科学基金面上项目14JCYBJC27800National Natural Science Foundation of China81670086,81370183;Chronic Disease Prevention and Control of Major Projects of Science and Technology in Tianjin17ZXMFSY00080;Tianjin Natural Science Foundation14JCYBJC27800