国家自然科学基金82170098;中国医学科学院医学与健康科技创新工程项目2020-I2M-2-009;广州市科技计划项目202102080611;广东省医学科学技术研究基金B2022157;National Natural Science Foundation of China82170098;The CAMS Innovation Fund for Medical Sciences2020-I2M-2-009;The Guangzhou Science and Technology Planning Project202102080611;The Medical Scientific Research Foundation of Guangdong ProvinceB2022157