国家自然科学基金71774147;浙江省基础公益研究计划LY21G030003;浙江省教育厅一般科研项目Y202146150;浙江省医药卫生科技计划项目2022KY910;National Natural Science Foundation of China71774147;Basic Public Welfare Research Program of Zhejiang ProvinceLY21G030003;General Scientific Research Project of Zhejiang Provincial Department of EducationY202146150;Medical and Health Science and Technology Program Project of Zhejiang Province2022KY910