国家自然科学基金82171915;上海市科技创新行动计划自然科学基金21Y11910300;上海申康医院发展中心重大临床研究项目SHDC2020CR4073;National Natural Science Foundation of China82171915;Natural Science Foundation of Shanghai Science and Technology Innovation Action Plan21Y11910300;Major Clinical Research Project of Shanghai Shenkang Hospital Development CenterSHDC2020CR4073