浙江省科技厅重大专项2013C03046;浙江省卫计委重点学科重点项目2015ZDA004;浙江省自然科学基金LY15H160054Key Project of the Scientific and Technological Department of Zhejiang Province2013C03046;the Key Funds for the Platform of the Health and Family Planning Commission of Zhejiang Province2015ZDA004;Natural Science Foundation of Zhejiang ProvinceLY15H160054