国家重点研发计划2022YFC2704200;北京协和医院中央高水平医院临床科研专项2022-PUMCH-B-083;中国医学科学院医学与健康科技创新工程2022-I2M-C&T-B-023;National Key Research and Development Program of China2022YFC2704200;National High Level Hospital Clinical Research Funding2022-PUMCH-B-083;Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences2022-I2M-C&T-B-023