Cancer and the environment: Filling knowledge gaps together

摘要：

@@ When considering disease etiology, we need to view the role of the environment along the continuum from health to disease for individuals because we know that there are complex interactions between genes, their molecular expression, and environmental factors over a person”s lifetime. We clearly have huge gaps in our knowledge along this continuum, and these gaps are natural opportunities for research. There are many factors to consider as we assess the relationship between environmental exposures over a lifetime. One factor is persistence of chemicals that ”live” beyond their initial intended use. Another factor is the fact that ”inert ingredients” are not really inert. ”Low dose” is also another consideration. We need to understand the biological effect of low dose exposure and we should clearly define what they mean by low dose research. For example, are we measuring the administered dose, or the internal/circulating dose?

机标关键词：environmental factors、biological effect、relationship、interactions、persistence、molecular、knowledge、exposure、natural、initial、complex、person、view、live

所属期刊栏目：04

分类号：R3(基础医学)

在线出版日期：2010-12-10（万方平台首次上网日期，不代表论文的发表时间）

页码：131-133