国家自然科学基金重点支持项目U1202224;云南省科技厅-昆明医科大学应用基础研究联合专项基金2013FB173;云南省卫生科技计划项目No.2012WS0051资助This study was supported by the grants from Key Project of National Natural Science Fund of China to Yunchao HUANGU1202224;Basic Research on Application of Joint Special Fund of Science and Technology Department of Yunnan Province-Kunming Medical University to Xiaobo CHEN2013FB173;Health Science and Technology Projects of Yunnan Province to Xiaobo CHEN2012WS0051