吴阶平医学基金临床科研专项资助基金课题320.6750.14171;广西壮族自治区卫生和计划生育委员会自筹经费科研课题Z2016085.Project supported by Wu Jieping's medical fund on clinical research320.6750.14171;Self-financing scientific research subject by Guangxi zhuang autonomous region,health and family planning commissionZ2016085