与蛋白结合的非共轭胆汁酸在小鼠大脑细胞浆中的独特存在

摘要：

@@ Bile acids are synthesized in the liver from cholesterol by the action of hepatic enzymes and excreted into the small intestine via the bile duct. In the intestinal lumen, they assist lipolysis and the absorption of fats by forming mixed micelles, and then return to the liver upon absorption in the ileum and proximal colon. Because of their efficient hepatic uptake, bile acids have low concentrations in the peripheral blood. Recent observations also indicate that the nuclear bile acid receptor regulates the bile acid pool by repressing transcription of genes encoding hepatocyte transporters”1” as well as cholesterol 7α-hydroxylase”2,3”, which is the rate-limiting enzyme for bile acid biosynthesis.

机标关键词：蛋白结合、共轭、胆汁酸、小鼠、大脑、细胞浆、独特存在、bile acid pool、peripheral blood、small intestine、bile duct

所属期刊栏目：22

分类号：O658(分析化学)

在线出版日期：2004-09-09（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：346-348