国家自然科学基金青年基金51308502;浙江省公益技术应用研究项目2015C33037;浙江省教育厅项目No.Y201329224Supported by the National Natural Science Foundation of China of Youth Fund51308502;the Public Welfare Technology Application Research Project of Zhejiang Province2015C33037;the Project of Education Department of Zhejiang ProvinceY201329224