国家自然科学基金No.40161554;浙江省自然科学基金No.LQ16C030004;温州市公益性科技计划项目No.S20140014;温州市水体污染控制与治理科技创新项目No.S20140037,S20140038,S20140039;温州医科大学人才科研启动基金项目No.QTJ14045Supported by the National Natural Science Foundation of China No.40161554,the Natural Science Foundation of Zhejiang Province No.LQ16C030004,the Public Welfare Science and Technology Plan Project of Wenzhou City No.S20140014,the Wenzhou Science and Technology Innovation Project for Water Pollution Control and Management No.S20140037,S20140038,S20140039 and the Scientific Research Fund of Wenzhou Medical University No.QTJ14045