国家高技术研究发展863计划项目2009ZZ06311;浙江省自然科学基金5100034;浙江省重大科技专项2010C13001;the National High-Tech Research and Development Program of China2009ZZ06311;the Natural Science Foundation of Zhejiang Province5100034;the Major Scientific and Technological Specialized Project of Zhejiang Province2010C13001