Interleukin-34:A new ligand for Colony-stimulating factor-1Receptor
1 IntroductionColony-stimulating factor-1 ( CSF1 ) is a important hematopoietic growth factor that is involved in the proliferation,differentiation,and survival of monocytes, macrophages, and bone marrow progenitor cells”1”.Its receptor (c-Fms) is known as the c-Fmsproto-oncoprotein”2”.By far the most definitive studies demonstrating biologic functions for CSF-1 in vivo are those in the op/op mutant mouse.The deficiency results from a single base-pair insertion in the coding region of the gene to product defective CSF-1”3-4”.Mice homozygous for this mutation have significant osteopetrosis,low growth rate,low body weight as well as a toothless phenotype because of a severe deficiency of osteoclasts and mononuclear phagocytes”5-6”,and are devoid of serum and tissue CSF-1 activity”7”.
hematopoietic growth factor、progenitor cells、CSF-1、significant、growth rate、bone marrow、body weight、survival、receptor、studies、results、product、region、far
R3 ;R28
2011-12-14（万方平台首次上网日期，不代表论文的发表时间）
共7页
495-501
