国家科技支撑计划2009BAI77B04,国家高技术研究发展计划“863”计划2008AA022602,上海市教委科研创新重点项目11ZS79,上海市卫生和计划生育委员会青年科研项目13QN168;Supported by Key Project in the National Science and Technology Pillar Program2009BAI77B04,National High Technology Research and Development Program of China " 863" Program 2008AA022602,Innovation Program of Shanghai Municipal Education Commission11ZS79,and Youth Research Program of Shanghai Health and Family Planning Commission13QN168.